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DNA metilazione e terapia del cancro di Moshe Szyf (inglese) libro copertina rigida-

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DNA Methylation and Cancer Therapy by Moshe Szyf (English) Hardcover Book
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Specifiche dell'oggetto

Condizione
Nuovo: Libro nuovo, intatto e non letto, in perfette condizioni, senza pagine mancanti o ...
ISBN-13
9780306478482
Book Title
DNA Methylation and Cancer Therapy
ISBN
9780306478482
Series
Medical Intelligence Unit Ser.
Publication Year
2005
Type
Textbook
Format
Hardcover
Language
English
Publication Name
D N A Methylation and Cancer Therapy
Author
Moshe Szyf
Item Length
9.2in
Publisher
Springer
Item Width
6.1in
Item Weight
21.4 Oz
Number of Pages
Xv, 239 Pages

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Product Information

NA methylation has bewildered molecular biologists since Hotchkiss discovered it almost six decades ago (Hotchkiss RDJ. Biol Cem 1948; 175:315-332). The fact that the chemical structure of our D genome consists of two components that are covalently bound, the genetic information that is replicated by the DNA replication machinery ana DNA methylation that is maintainea by independent enzymatic machinery, has redictably stimulated the imagination and curiosity of generations of mo- Edular biologists. An obvious question was whether DNA methylation was a bearer of additional information to the genetic information and what was the nature of this information? It was tempting to speculate that DNA me- thylation applied some form of control over programming of the genome s expression profile. Once techniques to probe the methylation profile of whole genomes as well as specific genes became available, it became clear that DNA methylation patterns are gene and tissue specific and that patterns of gene expression correlate with patterns of methylation. DNA methylation pat- terns emerged as the only component of the chemical structure of DNA that exhibited tissue and cell specificity. This data seemingly provided an attrac- tively simple explanation for the longstanding dilemma of how could one identical genome manifest itself in so many different forms in multicellular organisms? The DNA methylation pattern has thus become the only known factor to confer upon DNA a unique cellular identity.

Product Identifiers

Publisher
Springer
ISBN-10
030647848x
ISBN-13
9780306478482
eBay Product ID (ePID)
20038300592

Product Key Features

Author
Moshe Szyf
Publication Name
D N A Methylation and Cancer Therapy
Format
Hardcover
Language
English
Series
Medical Intelligence Unit Ser.
Publication Year
2005
Type
Textbook
Number of Pages
Xv, 239 Pages

Dimensions

Item Length
9.2in
Item Width
6.1in
Item Weight
21.4 Oz

Additional Product Features

Number of Volumes
1 Vol.
Lc Classification Number
Rc261-271
Table of Content
DNA Methylation.- Epigenetic Mechanisms of Gene Regulation.- DNA Hypo- vs. Hypermethylation in Cancer.- DNA Methylation in Urological Cancers.- DNA Methylation in Colorectal Cancer.- CpG Island Hypermethylation of Tumor Suppressor Genes in Human Cancer.- The Loss of Methyl Groups in DNA of Tumor Cells and Tissues.- Identifying Clinicopathological Association of DNA Hypermethylation in Cancers Using CpG Island Microarrays.- Methylation Analysis in Cancer.- Regulation of DNA Methyltransferases in Cancer.- Inhibition of Poly(ADP-Ribosyl)ation Allows DNA Hypermethylation.- The Role of Active Demethylation in Cancer and Its Therapeutic Potential.- Purine Analogues and Their Role in Methylation and Cancer Chemotherapy.- DNA Methyltransferase Inhibitors.- Preclinical and Clinical Studies on 5-Aza-2?-Deoxycytidine, a Potent Inhibitor of DNA Methylation, in Cancer Therapy.- Anticancer Gene Therapy by in Vivo DNA Electrotransfer of MBD2 Antisense.- Epilogue.
Copyright Date
2005
Topic
Biotechnology, Life Sciences / Biochemistry, Life Sciences / Genetics & Genomics, Oncology
Lccn
2004-022708
Dewey Decimal
616.99/406
Intended Audience
Scholarly & Professional
Dewey Edition
22
Illustrated
Yes
Genre
Science, Medical

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Ok so I ordered this item listed as having free shipping. It was listed at $43.54 with free shipping. Somehow I ended up being charged $65.52. Then after waiting 3 weeks and having absolutely no tracking information I spoke with the seller who agreed to send a replacment, but despite charging me extra money was unwilling to ship that replacment in a way that wouldn't take atleast 3 more weeks. Ultimately this was a complete waste of time and the seller is not one that I would recommend.
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The graphic novel arrived on time today and I'm looking forward to reading it and enjoying it. Walt Disney's Gargoyles is my most favorite animated/cartoon television series Disney created and I also collect Gargoyle-themed stuff, that includes literature on the series and subject in general.
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