Shape-shifting aliens have taken over the city! Fortunately for us, a trio of heroes called the Alien Busters have agreed to wipe out the attacking alien force. This Alien Busters team consists of the following members: a muscular man, an athletic woman, and a robot. Since each side-scrolling stage is filled with attacking aliens, players must punch, kick, and blast their way though them in order to advance.
Gordon, a tough guy with a bazooka, has a gunship for a special attack, while Karla has a flame-thrower for alien crisping and prefers to use a ballistic missile drop for her special weapon. Finally, Slammer the robot has an electric whip (among other devices) to smash aliens and can self-destruct at will. Special attacks can be done as many times as players want as long as their energy bars are filled. Picking up energy kits and health containers will help refill your life and special bar meters.
At the end of every stage, the game switches to a pseudo-3D perspective, where the action turns into a shooter of sorts. Players control a target as the game moves them through a building, and they must shoot every alien that emerges from the scenery. When this segment is complete, the stage ends, though some levels also have a boss character that must be exterminated. To take on these tough aliens, players will have to demonstrate quick reflexes or rely on the use of special attacks.