Puchi Puchi Virus is a fast-paced puzzle game with Japanese sensibilities and a trigonometric twist. It seems that the entire town has been infected with a strange virus that turns them into colorful animals, and it's up to Dr. Kevin and his nurses Honeydew and George the Chicken to destroy the viruses and cure the townsfolk. The viruses are arranged in a grid, and players must destroy them by tapping on three viruses of the same color to form a triangle. Viruses turn to stone if they aren't handled quickly, but everything inside of the triangles gets destroyed, so recovery isn't impossible. Each of the 102 patients serves as a level, and levels feature particular objectives requiring a certain number of points be scored or a specified number of viruses vanquished under the allotted time. A multiplayer mode is also available in which players clear the screen to send fireballs and viruses at their opponents.