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- Compralo SubitoPharmacological Guide to Metformin, Paperback by Lajoie, Natalie (EDT), Brand...
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Numero oggetto eBay:365566295981
Specifiche dell'oggetto
- Condizione
- Book Title
- Pharmacological Guide to Metformin
- ISBN
- 9781536166347
Informazioni su questo prodotto
Product Identifiers
Publisher
NOVA Science Publishers, Incorporated
ISBN-10
1536166340
ISBN-13
9781536166347
eBay Product ID (ePID)
20038629372
Product Key Features
Number of Pages
248 Pages
Publication Name
Pharmacological Guide to Metformin
Language
English
Publication Year
2019
Subject
Life Sciences / Anatomy & Physiology (See Also Life Sciences / Human Anatomy & Physiology), Pharmacology
Type
Textbook
Subject Area
Science, Medical
Series
Pharmacology-Research, Safety Testing and Regulation Ser.
Format
Trade Paperback
Dimensions
Item Weight
17.1 Oz
Additional Product Features
LCCN
2019-954056
TitleLeading
The
Illustrated
Yes
Table Of Content
Preface; The Pharmacogenetics of Metformin; Physicochemical and Pharmacokinetic Properties of Metformin Hydrochloride; Metformin: Who Are Suitable Patients?; Metformin Effects in Cancer Models; The Therapeutic Potential of Metformin in Breast and Ovarian Cancer; Index.
Synopsis
Almost six decades after its discovery, metformin still remains the gold standard drug for the management of type 2 diabetes mellitus, owing to its euglycemic property and cost-effectiveness. It is the most commonly prescribed and utilised oral antidiabetic drug worldwide. However, no two persons with the same phenotypical characteristics, such as age, gender, body weight and others, tend to respond similarly to equivalent doses of metformin. As such, the book first focuses on the various genetic polymorphisms that influence the therapeutic effects of metformin. Physicochemical, pharmacological, and pharmacokinetic properties of metformin will also be reviewed. The side effects of this drug can be dangerous. Metformin-induced lactic acidosis is a lethal disorder. The first significant deviation is gastrointestinal tract involvement. Common infection or the effect of metformin itself causes vomiting and diarrhoea, with subsequent hypovolemia causing pre-renal acute kidney injury, which in turn raises metformin levels up to toxic values. Development of kidney failure is often unexpected and fast. Following this, the authors explore the differences between healthy and cancer cells and how this may influence the metformin effect on these cells. In conclusion, the molecular mechanisms underlying the anticancer effects of metformin in breast and ovarian cancers are summarised, and the potential anticancer applications of metformin-based combinatorial chemotherapy are discussed., Almost six decades after its discovery, metformin still remains the gold standard drug for the management of type 2 diabetes mellitus, owing to its euglycemic property and cost-effectiveness. It is the most commonly prescribed and utilized oral antidiabetic drug worldwide. However, no two persons with the same phenotypical characteristics, such as age, gender, body weight and others, tend to respond similarly to equivalent doses of metformin. As such, The Pharmacological Guide to Metformin first focuses on the various genetic polymorphisms that influence the therapeutic effects of metformin.Physicochemical, pharmacological, and pharmacokinetic properties of metformin will also be reviewed.The side effects of this drug can be dangerous. Metformin-induced lactic acidosis is a lethal disorder. The first significant deviation is gastrointestinal tract involvement. Common infection or the effect of metformin itself causes vomiting and diarrhea, with subsequent hypovolemia causing pre-renal acute kidney injury, which in turn raises metformin levels up to toxic values. Development of kidney failure is often unexpected and fast.Following this, the authors explore the differences between healthy and cancer cells and how this may influence the metformin effect on these cells.In conclusion, the molecular mechanisms underlying the anticancer effects of metformin in breast and ovarian cancers are summarized, and the potential anticancer applications of metformin-based combinatorial chemotherapy are discussed.
LC Classification Number
QP801.M39P43 2020
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- c***m (429)- Feedback lasciato dall'acquirente.Ultimi 6 mesiAcquisto verificatoAAA+++; Excellent Service; Great Pricing; Fast Delivery-Faster Than Expected to Hawaii using free shipping USPS Ground Mail, Received 06/18; Paperback book in Great Condition as Described ; TLC Packaging; Excellent Seller Communication, Sends updates . Highly Recommended!, Thank you very much!
- n***m (110)- Feedback lasciato dall'acquirente.Mese scorsoAcquisto verificatoGood price for the book. Shipping was slow. Messaged the seller a week after I ordered it to see when they were going to ship it. They responded immediately and said it would be shipped out soon. Got it about a week later. Book did arrive in the date range that they provided though  Minimal packaging. Book is Shrink wrapped and only wrapped in thin plastic. No bubble wrap. Book is in good shape though. 
- c***t (923)- Feedback lasciato dall'acquirente.Ultimi 6 mesiAcquisto verificatoThe book I bought was reasonably priced and when it arrived it was in the 'Like New' condition specified in the listing. However, when I saw that the seller had not shipped the book after more than 15 days had passed since my order I felt I must write to say that I had actually placed an order with the seller and inquire when it planned to send the book. The brusque reply was that a tracking number was available, but no number HAD been created until I pointed out that I had placed the order.Catland by Hughes, Kathryn, Like New Used, Free shipping in the US (N° 356798982438)