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Specifiche dell'oggetto
- Condizione
- Book Title
- Systems Biology: Constraint-based Reconstruction and Analysis
- Publication Date
- 2015-01-26
- ISBN
- 9781107038851
Informazioni su questo prodotto
Product Identifiers
Publisher
Cambridge University Press
ISBN-10
1107038855
ISBN-13
9781107038851
eBay Product ID (ePID)
202752182
Product Key Features
Number of Pages
550 Pages
Language
English
Publication Name
Systems Biology : Constraint-Based Reconstruction and Analysis
Publication Year
2015
Subject
Life Sciences / Taxonomy, Life Sciences / Genetics & Genomics, Life Sciences / Biology
Type
Textbook
Subject Area
Science
Format
Hardcover
Dimensions
Item Height
1.1 in
Item Weight
44.8 Oz
Item Length
10 in
Item Width
7.2 in
Additional Product Features
Edition Number
2
Intended Audience
Scholarly & Professional
LCCN
2014-031793
Dewey Edition
23
Reviews
"[This textbook] offers a truly authoritative treatment of genome-scale systems biology modelling. [It] covers all aspects of this rapidly growing field from theory to basic and applied uses, also detailing open challenges with an emphasis on the multitude of constraint-based approaches by which phenotypic behavior can be inferred from biochemical wiring diagrams. The book is generously illustrated by figures and despite its great depth and breadth, it remains readily accessible ... researchers [will find it] a go-to guide for many years to come." Balzs Papp, Biological Research Centre, Hungarian Academy of Sciences, "... a very important and novel contribution to the systems biology literature. The field of systems biology is still in the phase of being defined as an independent field with a clear curriculum, but Palsson gives his very clear contributions to this. His definition of the paradigm of systems biology as components, networks, computer models and physiology is clearly explained and linked to educational modules, educational values and specific prerequisites. Thus, not only is he providing a fantastic novel textbook that enables teaching about network reconstruction and analysis, but he is also clearly defining this as the core of systems biology. I am therefore confident that the very well thought through structure of this textbook, where the reader is introduced to the different layers of network reconstruction and analysis, will be widely used for teaching systems biology worldwide." Jens Nielsen, Chalmers University of Technology, "One of the defining challenges of systems biology is to determine the structures and mechanisms by which complex networks of genes, proteins and metabolites control cell processes and molecular dynamics. Bernhard Palsson is a leading pioneer in constructing and analyzing genome-scale models of such networks. Here Palsson offers students an insider's guided tour of the concepts, principles and techniques underlying this emerging field. The book is brilliantly laid out and offers professors well-structured, much-needed material for a graduate-level course in systems biology and network science." James J. Collins, MIT, Broad Institute and Wyss Institute, "This is a real tour de force. With enormous clarity, Bernhard Palsson sets out the what, why and how of network and systems biology, and of the important role of genome-wide reconstructions - especially, to date, of metabolism - in realising it ... this is a masterful survey of the field by one of its leading practitioners. The development is nicely logical ... If you are interested in network biology at all, then this book is for you." Douglas Kell, University of Manchester, "One of the defining challenges of systems biology is to determine the structures and mechanisms by which complex networks of genes, proteins and metabolites control cell processes and molecular dynamics. Bernhard Palsson is a leading pioneer in constructing and analyzing genome-scale models of such networks. Here Palsson offers students an insider's guided tour of the concepts, principles and techniques underlying this emerging field. The book is brilliantly laid out and offers professors well-structured, much-needed material for a graduate-level course in systems biology and network science." James J. Collins, Massachusetts Institute of Technology, Broad Institute and Wyss Institute, "[This textbook] offers a truly authoritative treatment of genome-scale systems biology modelling. [It] covers all aspects of this rapidly growing field from theory to basic and applied uses, also detailing open challenges with an emphasis on the multitude of constraint-based approaches by which phenotypic behavior can be inferred from biochemical wiring diagrams. The book is generously illustrated by figures and despite its great depth and breadth, it remains readily accessible ... researchers [will find it] a go-to guide for many years to come." Balázs Papp, Biological Research Centre, Hungarian Academy of Sciences
Illustrated
Yes
Dewey Decimal
571.7
Table Of Content
Preface; 1. Introduction; Part I. Network Reconstruction: 2. Network reconstruction: the concept; 3. Network reconstruction: the process; 4. Metabolism in Escherichia coli; 5. Prokaryotes; 6. Eukaryotes; 7. Biochemical reaction networks; 8. Metastructures of genomes; Part II. Mathematical Properties of Reconstructed Networks: 9. The stoichiometric matrix; 10. Simple topological network properties; 11. Fundamental network properties; 12. Pathways; 13. Use of pathway vectors; 14. Randomized sampling; Part III. Determining the Phenotypic Potential of Reconstructed Networks: 15. Dual causality; 16. Functional states; 17. Constraints; 18. Optimization; 19. Determining capabilities; 20. Equivalent states; 21. Distal causation; Part IV. Basic and Applied Uses: 22. Environmental parameters; 23. Genetic parameters; 24. Analysis of omic data; 25. Model driven discovery; 26. Adaptive laboratory evolution; 27. Model driven design; Part V. Conceptual Foundations: 28. Teaching systems biology; 29. Epilogue; References; Index.
Synopsis
Reflecting the latest developments, this textbook explains how quantitative and computable genotype-phenotype relationships can be built using a genome-wide basis of information about the gene portfolio of an organism. It has been developed through extensive classroom use, providing a conceptual framework in addition to invaluable modelling tools and computational approaches., Recent technological advances have enabled comprehensive determination of the molecular composition of living cells. The chemical interactions between many of these molecules are known, giving rise to genome-scale reconstructed biochemical reaction networks underlying cellular functions. Mathematical descriptions of the totality of these chemical interactions lead to genome-scale models that allow the computation of physiological functions. Reflecting these recent developments, this textbook explains how such quantitative and computable genotype-phenotype relationships are built using a genome-wide basis of information about the gene portfolio of a target organism. It describes how biological knowledge is assembled to reconstruct biochemical reaction networks, the formulation of computational models of biological functions, and how these models can be used to address key biological questions and enable predictive biology. Developed through extensive classroom use, the book is designed to provide students with a solid conceptual framework and an invaluable set of modeling tools and computational approaches.
LC Classification Number
QH508 .P35 2015
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AlibrisBooks
98,6% di Feedback positivi•1,9 milioni oggetti venduti
Registrato come venditore professionale
Feedback sul venditore (513.169)
- m***m (2297)- Feedback lasciato dall'acquirente.Ultimi 6 mesiAcquisto verificatoI’m thrilled with my recent purchase . The website was user-friendly, and the product descriptions were accurate. Customer service was prompt and helpful, answering all my questions. My order arrived quickly, well-packaged, and the product exceeded my expectations in quality. I’m impressed with the attention to detail and the overall experience. I’ll definitely shop here again and highly recommend from this seller to others. Thank you for a fantastic experience!
- a***n (43)- Feedback lasciato dall'acquirente.Ultimi 6 mesiAcquisto verificatoMistakenly ordered a paperback that I thought was a hardcover, not sellers fault; it was described properly on the listing. Seller still processed a refund the day I went to return the item and let me keep the item anyway. A+++ service. Book arrived quickly in great condition and for a great price. Thank you so much! Amazing seller!
- n***c (94)- Feedback lasciato dall'acquirente.Ultimi 6 mesiAcquisto verificatoseller was communicative about my shipment, media mail took a while and tracking wasn't updated frequently, but seller communicated to me very quickly on status. the item came new and wrapped as described, though the packaging in it was packed wasn't sturdy and falling apart when it got to me.